General Information

  • ID:  hor006702
  • Uniprot ID:  O09035
  • Protein name:  Diazepam-binding inhibitor-like 5
  • Gene name:  Dbil5
  • Organism:  Mus musculus (Mouse)
  • Family:  ACBP family
  • Source:  Animal
  • Expression:  Expression is seen first at day 45 of post-natal development (post-meiotic transcription).|Exclusively expressed in late spermatids and spermatozoa. Not found in epididymis, spleen, bone marrow, skin, liver, brain, heart, kidney, muscle.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Mus (subgenus), Mus (genus), Murinae (subfamily), Muridae (family), Muroidea , Myomorpha (suborder), Rodentia (order), Glires , Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0000062 fatty-acyl-CoA binding; GO:0008289 lipid binding
  • GO BP:  GO:0006631 fatty acid metabolic process
  • GO CC:  GO:0005737 cytoplasm

Sequence Information

  • Sequence:  MSQVEFEMACASLKQLKGPVSDQEKLLVYSFYKQATQGDCNIPVPPATDVRAKAKYEAWMVNKGMSKMDAMRIYIAKVEELKKKEPC
  • Length:  87(1-87)
  • Propeptide:  MSQVEFEMACASLKQLKGPVSDQEKLLVYSFYKQATQGDCNIPVPPATDVRAKAKYEAWMVNKGMSKMDAMRIYIAKVEELKKKEPC
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May be involved in the energy metabolism of the mature sperm.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-O09035-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-O09035-F1.pdbhor006702_AF2.pdbhor006702_ESM.pdb

Physical Information

Mass: 1139877 Formula: C436H703N113O128S9
Absent amino acids: H Common amino acids: K
pI: 8.83 Basic residues: 14
Polar residues: 19 Hydrophobic residues: 27
Hydrophobicity: -42.41 Boman Index: -12969
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 69.54
Instability Index: 5898.28 Extinction Coefficient cystines: 11585
Absorbance 280nm: 134.71

Literature

  • PubMed ID:  8898349
  • Title:  A novel endozepine-like peptide (ELP) is exclusively expressed in male germ cells.
  • PubMed ID:  10951202
  • Title:  Structure and expression of the mouse gene encoding the endozepine-like peptide from haploid male germ cells.
  • PubMed ID:  15489334
  • Title:  The status, quality, and expansion of the NIH full-length cD
  • PubMed ID:  21183079
  • Title: